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All investigations were performed after approval by the Ethical Committee of the University of Lodz (decision identification code: 9/KBBN-U/II/2017, approved on 6 November 2017)

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Moreover, released HMGB1 further binds to Toll-like receptor 4 (TLR4) on DCs, upregulating major histocompatibility complex (MHC) I/II and co-stimulatory markers such as CD80/CD86, which collectively facilitate DC migration to draining lymph nodes and efficient antigen presentation to nave T cells (Lau et al., 2020

Guarana stimulates lipid degradation and helps reduce fluid retention in our body, thus facilitating weight loss, when combined with a hypocaloric diet