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For example, in non-dialysis CKD, paricalcitol did not reduce LV mass or improve cardiac function in PRIMO and OPERA despite biochemical effects, while in hemodialysis the J-DAVID trial found no reduction in cardiovascular events with oral alfacalcidol

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The Wnt--catenin pathway is pivotal for intestinal cell specification, enabling Wnt proteins, mostly secreted by mesenchymal and Paneth cells, to trigger signaling in neighboring cells 17