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This GHR upregulation sensitises local cells to circulating GH, potentiating GH-induced JAK2/STAT signalling and stimulating collagen matrix synthesis, IGF-1 production, and fibroblast proliferation providing a mechanism through which BPC-157 engages the GH/IGF-1 axis at the tissue level without altering systemic GH secretion

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View Study [4]"The influence of synthetic DSIP on disturbed human sleep" Schneider-Helmert D, Schoenenberger GA, 1981 Finding: Chronic insomniacs receiving DSIP had longer sleep duration, higher quality sleep with fewer interruptions, and slightly more REM sleepbut no daytime sedation