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270 Overall, HDAC8 enforces the transcriptional repression of ATGs, especially under metabolic stress, thereby positioning it as a potential therapeutic target
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Flucytosine, a synthetic fluorinated pyrimidine used to treat fungal respiratory tract infections, has also been shown to inhibit expression of the pyoverdine siderophore-biosynthesis gene in Pseudomonas aeruginosa , and subsequently suppress pathogenicity in a mouse model of pulmonary infection ( P
Histone modifications: Affects histone acetyltransferases and deacetylases changing chromatin structure
Katz RL, He W, Khanna A, Fernandez RL, Zaidi TM, Krebs M, Caraway NP, Zhang HZ, Jiang F, Spitz MR, Blowers DP, Jimenez CA, Mehran RJ, Swisher SG , Roth JA, Morris JS, Etzel CJ, El-Zein R
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