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Studies show that the transcription factor FOXO4 plays a protective role in senescent cells by maintaining the protein p53 in a sequestrated state within nuclear structures, thereby inhibiting its ability to initiate apoptosis

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This exceeded outcomes reported for semaglutide (~15%) and tirzepatide (~22%) in comparable timeframes, representing the largest effect size for any metabolic peptide in published Phase II data at that time

Kona, W.M.F