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The practice of doubling the infusion rate is increasingly accepted, but tripling or quadrupling the dose remains more controversial

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In both situations, antigen-specific T cells undergo clonal expansion upon the engagement and activation of antigens

In addition, IL4R is highly expressed in M2-polarized, protumoral TAMs compared with M1-polarized, antitumoral macrophages, making IL4R a potential target for targeted drug delivery to TAMs 31,32

Science & studies 4.1 Key publications Before going into the details of the individual studies, here are 6 key publications on which the BPC-157 evidence base rests: Sikiric P., Seiwerth S., Rucman R., et al