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In the arcuate nucleus of hypothalamus, two distinct neuronal populations exist: orexigenic neurons expressing hypothalamic agouti-related peptide/neuropeptide Y (AgRP/NPY) and anorexigenic neurons expressing proopiomelanocortin (POMC), which play integral roles in responding to peripheral hormones and nutrients, thereby maintaining energy homeostasis and regulating glucose metabolism [94]

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Journal of experimental pharmacology, 4, 149155.

Yes, Glutathione can help lighten and brighten the skin, but it works gradually and naturally rather than giving an instant bleaching effect