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Based on the obtained results, we can speculate that cigarette smoking may enhance the function of these desaturases, but the role of the presence of the C4 double bond in the sphingoid backbone of ceramide in the skin barrier function needs to be further elucidated

Ethical approval for the study was obtained from the Scientific Research Ethics Committee of the University of Health Sciences, Trabzon Faculty of Medicine (Approval No: 2025/176

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