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The blood serum from the people who regularly vaped, although not from those who regularly smoked, increased endothelial cell permeability allowing for more substances to pass through the cells and making them behave more like those in leaky blood vessels, which can cause tissue edema

Using a PK study to quantify plasma nicotine concentration following the use of e-cigarettes and combustible cigarettes, we compared different products and e-liquids to assess the effect of delivery of greater aerosol mass, protonated versus unprotonated nicotine, and increasing e-liquid nicotine concentration on both nicotine delivery and subjective consumer product liking

Bureau of Alcohol, Tobacco, Firearms and Explosives

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(ed.) U.S