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Although protonated nicotine is not volatile, unprotonated nicotine is volatile and is able to enter the gas phase and readily pass into lipid membranes
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Additional sporadic findings included posterior cerebral artery hypoplasia, intracranial aneurysm, vertebral artery tortuosity, atrioventricular block, tricuspid valve prolapse, interatrial septal aneurysm, bicuspid aortic valve, delayed right ventricular conduction, left ventricular thickening, ventricular arrhythmia, tachycardia with extrasystoles, arteriovenous fistula, and deep venous thrombosis (Additional Table 1)