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Supportive evidence also comes from finding that a BP-induced regression of OD, such as LVH and urinary protein excretion, may be accompanied by a reduction of fatal and nonfatal outcomes , although this evidence is obviously indirect, being derived from post-hoc correlative analyses of randomized data

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Some public health experts have proposed e-cigarettes as a reduced harm alternative to cigarettes for those not interested or able to quit, citing reports like one from the National Academies of Sciences, Engineering and Medicine, which found that substitution of e-cigarettes for combustible cigarettes reduced users exposures to carcinogens and other harmful toxicants

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