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Concurrently, mitochondrial ROS (mtROS) amplifies vascular dysfunction by oxidizing BH4, uncoupling endothelial eNOS, and reducing NO bioavailability while also activating pro-inflammatory pathways (e.g., NLRP3 inflammasome) and stimulating NOX activity, creating continuous oxidative damage (Penna and Pagliaro, 2025)

Expression of ghrelin and its receptor in human tissues

42, 43, 44 Finally, in a prospective study in 952 postmenopausal women, an impairment in endothelial function was shown to be an efficient independent predictor of the development of arterial hypertension during a follow-up of 3.6 years

Sermorelin is a xanthine oxidase inhibitor and a peptide hormone that stimulates release of the growth hormon

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