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examined whether genetic variations in the cytochrome and drug transporter system are associated with the effect of smoking on clopidogrel response by measuring clopidogrel on-treatment platelet reactivity in 1,431 consecutive patients (smokers n=249) who underwent coronary angiography

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Carbon monoxide from cigarette smoke impairs oxygen transport, which can damage arterial walls and make cholesterol stick more easily

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The yield of tobacco tar is related to the frequency of smoking