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Anything that disturbs the smoke-infused surface can release the chemicals

The same study did find a statistically significant increased risk of stroke in never-smokers who used snus, so the cardiovascular profile for snus is far cleaner than cigarettes, but not a clean bill of health

Plus, some story missions have set-pieces too, so the developers already expected you to go these specific routes thats supposedly of your own

And just do a lot of new problems, like a lot of exploring and finding things and you didn't have to go far