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Several other modulators have been found to promote neurogenesis, reduce the size of infarcts and promote neurological recovery in the brain after HIBD, as follows: Vascular endothelial growth factor (VEGF) binds to the VEGFR2 receptor and activates the Rho/Rok pathway, promoting synaptic growth and playing a crucial role in neuroprotection and neurogenesis ( via the BDNF-TrkB-CREB signaling pathway ( Therapeutic measures for neonatal HIBD to promote endogenous neurogenesis The ability of spontaneous endogenous neurogenesis after neonatal HIBD to repair damaged neurological functions is markedly limited

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Ann Intern Med 64:817, 1966