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A couple limitations to this study include the limited information to calculate PTPs for all individuals on the sequencing panel, and the inability to comment on the sensitivity of the MPC in the Mori and Pacific population, as we did not examine confirmed cases of monogenic diabetes

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Table 2 Number of cardiovascular disease mortality and YLDs attributable to smoking by gender and SDI regions globally in 1990 and 2021, and the percent change from 1990 to 2021 (based on GBD 2021 study data) Table 3 Age-standardized mortality and YLDs rates of cardiovascular disease attributable to smoking by gender and SDI regions globally in 1990 and 2021, and time trends from 1990 to 2021 (based on GBD 2021 study data) Figure 1 Global age patterns of cardiovascular disease burden attributable to smoking by gender in 2021: Death cases and mortality rates Figure 2 Global age patterns of cardiovascular disease burden attributable to smoking by gender in 2021: YLDs and YLD rates SDI and its role in shaping disease burden In 2021, the mortality and YLDs attributed to CVD due to smoking were lower in low-SDI regions compared to other regions (Table 2)