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Cancer 35 , 6572 (1998)

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Future research should also address whether CSE-induced downregulation of glycolytic flux is caused by disruption of the transcriptional activity of HIF-1 or by a recently reported mechanism by which HIF-1 is involved in the cytoplasmic formation of a metabolic complex involving several glycolytic enzymes [63]

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Diseases like Huntington's and Kennedy syndrome are examples of diseases caused by these mutations

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