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The CO that is inhaled when smoking results in the formation of carboxyhemoglobin (COHb), which adversely affects both mother and fetus since it reduces the oxygen carrying capacity in the blood and can lead to fetal hypoxia 11,25

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Cigarette smoking affects the skin health through different mechanisms, such as disturbing the balance of skin microbiome, promoting the pro-inflammatory cytokines, perturbing the balance in the protease/antiprotease systems, regulating the dermal microvasculature and degrading the skin collagen (Lahmann et al., 2001