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It has been proposed that deficiency of intracellular cysteine induces ferroptosis primarily due to failure to synthesize GSH, which protects cells against ROS and lipid peroxidation 18

A reliance on animal experiments may be misleading, given the substantial changes, not only in UA metabolism but also in its transport, associated with primate evolution 62

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POSSIBLE CAUSES AND CONSEQUENCESGLUTATHION DEFICIENCY