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This may be one of the driving factors which deter nicotine users with depression from quitting, especially among those who are using nicotine products to self-medicate

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Health and economic costs associated with tobacco use in Canada were estimated at $12.3 billion for the year 2017

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In that time, a severe lung disease related to vaping emerged and led to the hospitalization of thousands of otherwise young and healthy individuals, and not enough time has passed since the introduction of e-cigarettes to accurately estimate any long-term health damage