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The pathogenesis involves nicotine/acetylcholine-induced follicular occlusion, follicular rupture, and immune dysregulation

In other words, the body (mainly the brain) needs nicotine to release dopamine, a neurotransmitter that regulates mood and the reward system

We also used a p53 reporter assay to assess p53 activity in response to CSE in lung fibroblasts

Zengerle, Jason (2026)

Youth have easy access to e-cigarettes online through lax age verification and concealed deliveries TikTok accounts promoting discreet shipping services that conceal e-cigarettes in cosmetics, candy, and beauty products attempt to circumvent age restrictions on e-cigarette sales as well as parental oversight, according to new Truth Initiative research published in Tobacco Control