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In the NMDA-induced olfactory bulbs (OB) excitotoxicity model, the expression of SIRT1 and SIRT4 in OB increased, while the expression of SIRT2 did not increase, which may be related to the recovery of olfactory function [123]

The lack of a single target has made DSIP harder to develop as a pharmaceutical, but the same versatility is partly why it has attracted research interest across different therapeutic areas

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