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Kids who smoked were often thought of as cool, brazen, and ahead of the curve

The crux is living long enough to enjoy these benefits

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By enhancing the activity of the nicotinic acetylcholine receptors (nAChRs) in the brain, nicotine increases several feel-good chemicals (mostly dopamine but also serotonin, GABA, endogenous opioids, and endorphins) that may be lacking in the brains of people with ME/CFS, FM and long COVID

Unsurprisingly, cotinine levels were much higher due to nicotines shorter half-life (~ two hours) compared with that of cotinine (~ 16 h) (mean nicotine: 12.5 6.6 ng/ml