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Intriguingly, parts of the ventral striatum (nucleus accumbens, and ventral caudate) appear to show a relative signal decrease in response to smoking in this experiment, as well as a large region in the orbitofrontal cortex

(See the Al Pacino and Russell Crowe vehicle The Insider if you want Hollywood's take on that story.) Eventually, Big Tobacco was forced to admit that their product was hazardous

My grandmother was unable to go but a few hours without smoking

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This has important implications for what policy the United States should implement. The analysis synthesized the results of 37 experiments that had all tested the impact of picture-based versus text warnings