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One possible explanation for the apparent paradox was proposed by Nouri-Shirazi and Guinet who stated that DCs developed in a nicotinic environment fail to support the terminal development of effector memory Th1 cells due to their differential expression of costimulatory molecules CD86 and CD80 and lack of IL-12 production [245]

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People who typically smoke more than 10 cigarettes daily may consider starting on a 21 mg dose