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In summary, data from both human and animal studies indicate that Th17 cell is actively involved in worsening smoking-associated inflammation and autoimmune diseases, including COPD, CD, colitis, RA and psoriasis, although nicotine can mitigate colitis in mice via suppression of IL-17 expression

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J Orthop Trauma 36(4):e122e128 Yang Y, Tang T, Chen M, Xiang M, Li L, Hou X (2020) Prevalence and association of anxiety and depression among orthopaedic trauma inpatients: a retrospective analysis of 1994 cases