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It is noteworthy, though, that since 2002, the number of people who have managed to quit smoking exceeds that of active smokers (CDC, 2016b, para

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They also found that PNE increased the expression of the D5 dopamine receptor in the striatum but did not influence exploratory locomotion, the delay-discounting test, or the expression of other dopamine-related genes ( DRD4 , DAT1 , NR4A2 , and TH ) in either the PFC or the striatum [80]

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Nicotine reaches the brain within seconds and activates reward systems linked with dopamine, a chemical associated with pleasure and motivation