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In all groups, the two most frequently reported symptoms included item 6: continued tobacco use despite knowledge of having a persistent or recurrent physical or psychological problem and item 2: a persistent desire or unsuccessful effort to cut down or control tobacco use

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They may describe being easily confused, unmotivated, or frustrated, and if the condition persists, they may feel anxious or depressed about their circumstances

Of interest is that these effects were supported by the modulation of C

Delaying care may lead to complications or prolonged discomfort