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Nicotine addiction is no different and its properties include: Psychoactive effects Compulsive use Quick relapse Drug-reinforced behavior Tolerance Physical dependence Nicotine can act as both as a stimulant and a sedative, depending on the quantity you ingest

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[6] Indole alkaloids are also present in leaves and stems which includes harmala alkaloids as well

Researchers have proposed that, in addition to ceremonial use, cohoba may have also been used in healing practices or as a stimulant in everyday contexts