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The combustion of tobacco produces thousands of chemicals, including tar, carbon monoxide, and numerous toxic substances known to damage the lungs, heart, and blood vessels

Unlike the machine, the addicted smoker has neither a stopwatch nor a device to measure the volume of the puffs they inhale

They do point out that routine data on smoking gathered by the Australian government back these findings up

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It seems that the overall effect of cigarette smoking on the skin barrier function depends on the balance between oxidative damage and the counteracting compensatory processes