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In addition to the targeted use of nicotine as a pesticide or as an ecological means of combating plant pests with tobacco brew (see, in German, Nicotine from Tobacco a Natural Method Against Plant Pests?), quantities of nicotine found can also stem naturally from the plant itself, or be the result of contamination from tobacco dust or smokers hands

Some previous international studies recommended sequential therapy as an alternative and documented improved success rates

Active and passive smoking enhances the risk of diabetes mellitus type 2 [4]