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This ultimately led to him switching entirely

Nat Genet (2015) 47:110713

Nicotines stimulation of these receptors may enhance cognitive functions and neuronal resilience, suggesting a potential therapeutic pathway for slowing the progression of Alzheimers (NCBI, 2021)

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[97] On 8 December 2003, Osbourne was rushed into emergency surgery at Slough's Wexham Park Hospital following an accident with his quad bike on his estate in Jordans, Buckinghamshire