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PRDX1 stabilizes NFE2L2 by inhibiting cullin 3 (CUL3)-mediated ubiquitination, thereby promoting transcription of genes involved in GSH synthesis ( GCLC , GCLM ) and cystine import ( SLC7A11 ) 113

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Considering muscle mass maintenance and the putatively beneficial effects of ketosis, KDs and STS should be compared with chronic CR or protein restriction in clinical studies

GSH exists predominantly (99%) in the thiol-reduced form and the remaining amount undergoes thiol oxidation to form GSH-disulfide or mixed-disulfides with target proteins

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