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Gootter Foundation, the Taiwan Ministry of Science and Technology, the Royal College of Physicians and Surgeons, the Leducq Foundation, and the Tobacco-Related Disease Research Program.

Acknowledgements We wish to thank Karl Fagerstrm for his support during the conceptualization of the study, data interpretation, and critical review of the manuscript

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When you consider the 5.6 trillion used-cigarettes, or 766,571 metric tons that are deposited into the environment worldwide every year, the advantages of such a material become even more evident