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Under such circumstances, the agent can be regarded operationally as an incomplete carcinogen. A cell that has undergone the irreversible change that permits its ultimate neoplastic transformation may be phenotypically indistinguishable from adjacent normal parenchymal cells

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These findings support the interpretation that the lower odds of hypertension observed in our study among exclusive e-cigarette users, who were overwhelmingly former smokers, may partly reflect the removal of combustible tobacco exposure, though the contribution of healthy switcher bias and residual confounding cannot be disentangled in cross-sectional data

Everyone who has seen a hot air balloon, knows that hot air moves upwards, and colder air moves downwards