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The researchers stressed that the study does not directly measure disease outcomes in humans
Previous studies showed that the expression of xCT gene and protein is decreased by chronic nicotine exposure (Hammad et al., 2021), which may be a homeostatic mechanism that compensates for exaggerated glutamate release in response to acute nicotine exposure

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FIGURE 4 4 Discussion The main findings of the present study were as follows: 1) Different types of nicotine salts increased the release of DA in the NAc