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Symptoms must be present in two or more settings before the age of 12 and for at least 6 months and are required to impair occupational, social, or academic functioning [20, 58]

Its now known that 17 cancer types are linked to smoking, that obesity raises cancer risk and that fewer people smoke

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Risk of bias assessment of studies included, based on Newcastle-Ottawa Scale (Nos) for observational studies, Risk of Bias 2 (RoB2) for randomized trials, and SYRCLEs Risk of Bias tool for animal studies The biological mechanisms linking tobacco smoking to endometriosis remain complex and incompletely understood