From exclusively statistical numbers, the latest study of the serious organization "Japan Tobacco" showed drastic decreases of the number of smokers: from 36,5% in 1995 (and up to 83% of all Japanese men in 1966!), they were not more than 21,7% adults (and 10% of all women) in 2011, and then 17,7% in 2018 (29,4% of men and 7,2% of women)
Cigarettes deliver nicotine very rapidly, plus thousands of toxic chemicals, including dozens of carcinogens
Its not a restriction on progress, put it that way
One observation: if you're holding a conversation, the device occasionally ends the session before you've used all 14 puffs
Knowing the risk factors that contribute to this cancer is an important step in protecting your health