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doi: 10.1093/clinchem/43.12.2281, PMID: [DOI] [PubMed] [Google Scholar] 18.Dove MS, Dockery DW, Connolly GN

Changes in your skin barrier may cause you to develop symptoms of atopic dermatitis Tobacco smoke negatively affects your skin barrier and immune system in multiple ways

These are non-negotiable: - Protective gear - Wear gloves, eye protection, and even a mask if dealing with nicotine concentrates - Ventilation - Nicotine vapours or strong flavourings can irritate so have a window open or a fan nearby - Labels - Put labels on everything, including information about the date of creation, nicotine strengths, ratio of ingredients and the flavour - Safe storage - Concentrated nicotine is a toxin, so store it very carefully and avoid contact with skin - Clean, sterilised tools - Pipettes, beakers, and bottles should all be thoroughly sterilised to avoid contamination - A DIY calculator - Getting your ratios right will avoid overdosing or underdosing, so an e-liquid calculator is your friend - Responsible disposal - Leftover concentrates, used containers, and any other waste should be cleaned up and discarded safely And, most importantly, ALWAYS keep chemicals out of reach of kids and pets

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Nicotine and the many substances found in cigarette smoke promote the narrowing of blood vessels, inflammation and changes in blood circulation