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Sci Rep 7(1):2028

Cancer Epidemiol Biomarkers Prev 18:33213333 Piad JJ, Wajrock S, Jaccard G, Janeke G (2013) Formation of mainstream cigarette smoke constituents prioritized by the World Health Organization Yield patterns observed in market surveys, clustering and inverse correlations

They base these decisions on the available evidence, but tend to build in a margin of error too

Government Regulations One of the biggest factors