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To achieve this, there are two major alternative methodological approaches: (i) overexpression of selected metal transport genes or expression under tissue- or cell-specific promoters

Similarly, systemic necrosis is often induced when Tm-2 2 scion/rootstock is grafted with ToMV-susceptible or Tm-1 rootstock/scions

Additionally, it must be noted that both nicotine and by-products of TS and e-cigs such as polycyclic aromatic hydrocarbons are inducers of CYP1A2, hence deciphering their individual role in interaction with anti-psychotics can be beneficial for clinical translation (Zevin and Benowitz 1999