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We categorised ISEI based on the distribution of the study population, separately for men and women: We combined the three middle quintiles to distinguish between the highest 20% (high), the middle 60% (intermediate), and the lowest 20% (low ISEI)

Pain level is assessed and treatment adjusted using stepwise analgesic regimens (level 1, level 2)

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Its also found in some plants used as flavorings, such as guarana, or alternative teas popular in South American, such as yerba mate (Ilex paraguariensis) and Ilex guayusa