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In the latest study, published in this week's issue of the journal Science, researchers at the University of Southern California and University of Iowa found that longtime smokers who had sustained insula damage had a remarkably easy time giving up cigarettes

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in others, they are placed in a room with high humidity

All this evidence implies that cigarette smoke, as an environmental trigger, interacts with susceptible genes and immune systems with proinflammatory propensity before exerting its influence to trigger SLE and perpetuate SLE-related inflammation in certain subsets of individuals 52 62