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We know the phenomenon

Combination NRT and varenicline improve this to approximately 25-35%, but the high relapse rate often within the first 8 weeks limits per-patient product revenue cycles and may discourage repeated purchase among disappointed quitters, constraining organic retail sales growth

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Drasler B, Sayre P, Steinhuser KG, Petri-Fink A, Rothen-Rutishauser B