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CS emitted from burning cigarettes has been recognized as a significant contributor to exacerbation of diseases, not only within the respiratory system but also in systemic organs that lack direct exposure to CS itself ( Although exposure to CS has been shown to impact the onset and progression of diseases by regulating the expression of miRNAs in various organs ( Materials and methods Animals Animal maintenance and experimental procedures were conducted in accordance with the guidelines set by the Animal Care and Ethics Committees of the Korea Institute of Toxicology (KIT

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