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16 Furthermore, pyruvate can be converted into acetyl-CoA by pyruvate dehydrogenase complex, entering the mitochondria to supply the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS), providing an efficient energy source for alveolar epithelial cells, alveolar macrophages, and other immune cells

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The number of worst-case scenarios will likely be low, much lower than the number of nonsmokers helped

Sales have plunged from 2.5 billion packs in 1998 to 972,000 in 2011