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This defective desquamation prevents normal debridement resulting in excessive growth and thickening of the filiform papillae that then collect debris, bacteria, fungi or other foreign materials which contribute to the discoloration

Cardiovasc Res 114(10):13101312 Munzel T, Hahad O, Daiber A (2019) Double hazard of smoking and alcohol on vascular function in adolescents

(2006) Smoking interacts with genetic risk factors in the development of rheumatoid arthritis among older Caucasian women

Evidence suggests that nicotine is a muscle stimulant, which can lead to increased bruxism (grinding of teeth)

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