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Shameless star David Threlfall says he still thinks it's 'a story about people trying to get by' Hes played Frank Gallagher for the last decade and, as Shameless bids farewell, David Threlfall talks to Susan Griffin After nine years, The Jockey pub is calling time as Shameless, (Channel 4 on 10pm Tuesday) the show that launched the careers of James McAvoy, Anne-Marie Duff and Maxine Peake, draws to a close with an eleventh and final series

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Caffeine, alcohol, smoking, and reproductive outcomes among couples undergoing assisted reproductive technology treatments