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14) that can signal the release of neurotransmitters such as dopamine, norepinephrine, acetylcholine, GABA, and glutamate involved in reward pathways, transmission at the neuromuscular junction, and cognition (Figures 2, 3) [Figure 2) [ FIGURE 2 FIGURE 3 Brain imaging studies have demonstrated that nicotine acutely increases the activity in the visual system, PFC, and thalamus which are consistent with activation of the corticobasal ganglia-thalamic brain circuits [Figure 4) [ FIGURE 4 While electronic cigarettes (e-cigarettes) do not produce combusted smoke, they do deliver an aerosol containing nicotine and other tobacco-related compounds [26]

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But many dont die from drug overdoses or suicide the kinds of things you might suspect in severe psychiatric illness