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Cold Spring Harb Perspect Biol 5:a012914 Jorgensen ED, Zhao H, Traganos F, Albino AP, Darzynkiewicz Z (2010) DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco-and nicotine-free cigarettes

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Also with long term smoking, the multiple harmful chemicals in cigarette smoke, causes hardening of smooth muscles in walls of vessels of the body generally, including those to the heart, brain, kidneys and penis